Aflatoxins are among the most hazardous mycotoxins affecting poultry production, causing severe economic losses and adverse health effects, particularly in highly susceptible species such as ducks. This study was conducted to evaluate the protective efficacy of dietary mycotoxin binders against aflatoxicosis induced by aflatoxin B1-contaminated feed in Pekin ducks. A total of 250 one-day-old Pekin ducklings were randomly allocated into five equal experimental groups (50 birds/group). Group 1 served as the negative control and received a basal uncontaminated diet, while Group 2 received feed contaminated with aflatoxin B1 at a concentration of 75 ppb without binder supplementation. Groups 3, 4, and 5 received feed contaminated with aflatoxin B1 at a concentration of 75 ppb and supplemented with mycotoxin binder at doses of 0.5, 1.0, and 1.5 kg/ton feed, respectively. The experiment lasted for 45 days under controlled management conditions. Growth performance parameters, including live body weight, body weight gain, feed intake, and feed conversion ratio (FCR), were evaluated weekly. Hematological indices, including red blood cell count (RBC), hemoglobin concentration (Hb), packed cell volume (PCV), white blood cell count (WBC), lymphocyte percentage, and heterophil percentage, were assessed on days 15 and 25. Serum biochemical analyses included alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine, and C-reactive protein (CRP). The results demonstrated that aflatoxin exposure significantly reduced live body weight, body weight gain, feed intake, RBC count, Hb concentration, and PCV%, while significantly increasing FCR, WBC count, heterophil percentage, liver enzymes, renal function markers, and CRP levels compared with the negative control group (P≤0.05). Dietary supplementation with mycotoxin binders significantly ameliorated these adverse effects in a dose-dependent manner. The highest binder dose (1.5 kg/ton) showed the greatest protective efficacy, restoring most productive, hematological, and biochemical parameters near normal values. Correlation analysis revealed strong negative relationships between aflatoxin toxicity markers and productive performance, while positive correlations were observed between hematological recovery and growth indices. In conclusion, the use of mycotoxin binders can be considered an effective nutritional strategy for minimizing aflatoxin-related losses in duck production systems.