Background: The intensity of sickle cell anemia (SCA) is significantly modified by fetal hemoglobin (HbF). However, in eastern Sudan, HbF estimation is not a common trend. Additionally, scarcity is known to be the connection between HbF and the intensity of SCA in afflicted patients. This study aimed to identify the impact of fetal hemoglobin on disease severity in eastern Sudanese sickle cell patients. Materials and Methods: A cross-sectional descriptive study was implemented from January 2013 to December 2015. Twenty-six patients were enrolled in the trial. The hematological outcomes and HbF were consecutively verified using a hematology analyzer and capillary electrophoresis. Results: The average HbF level across the 26 SCA patients was 9.8±6.3%. Males showed considerably lower mean levels of HbF than females, 7.7±5.8% vs. 10.6±6.7%, respectively (P = 0.222). The mean fetal hemoglobin levels of 18 patients (69.2%) with severe disease were significantly above those of 8 patients (30.8%) with moderate disease (7.1±10.4% vs. 4.7±6.0%, respectively). A statistically insignificant link existed between the average HbF levels for patients with complications (7.4±10.3) and those without complications (4.7±6.3) (P= 0.371). Conclusion: It is found that the scale of HbF dramatically inversely correlates with the clinical course of the disease in eastern Sudanese patients with sickle cell anemia. To lessen the morbidity and mortality among these patients, it is advised that tools for early determination of fetal hemoglobin and HbF induction be made accessible.