Persistent (repeated or long-term) use of aphrodisiacs among men is influenced by a combination of biological, psychological, social, cultural, and economic factors. These determinants vary across settings but commonly reflect men’s perceptions of masculinity, sexual expectations, relationship dynamics, and health-seeking behaviors. Fear of sexual underperformance can drive continued use of aphrodisiacs as a coping mechanism. Men who perceive themselves as sexually inadequate may rely on aphrodisiacs to boost confidence. Work stress, financial stress, and family responsibilities can create psychological conditions that lead men to seek sexual enhancement substances. This study is aim to evaluate the Determinants of Persistent Aphrodisiac Use among Men in Urban Communities of South-South Nigeria. This was a cross-sectional study involving 250 men. A well-structured questionnaire was administered to participants. The study lasted for a period of 2 months. Statistical analysis was done using SPSS version 25.0 and p < 0.05 was significant. The results revealed that 72% of the participants have reduced self-esteem, 86% had erectile difficulties or declining sexual function, 75% had peer influence, 65% had relationship pressure, 75% had stigma around sexual dysfunction, 80% had limited access to sexual health services, 96% had health issues, 68% had habit formation and 85% said it was affordable and accessible. The study shows that persistent or repeated use of aphrodisiac substances is shaped by multiple interrelated factors and these determinants can be grouped into psychological, physical/health-related, sociocultural, economic, and behavioral factors.