Abstract: In today’s rapidly evolving industrial and technological landscape, achieving project management excellence is essential for organizations striving for efficiency, agility, and sustained competitiveness. As projects grow in complexity, the demand for higher quality, proactive risk management, and optimal resource utilization increases, necessitating a structured, data-driven approach for strategic alignment and execution. This study explores the role of Lean Six Sigma (LSS) in project management, integrating Lean’s waste reduction with Six Sigma’s precision to enhance performance, resource optimization, and governance. The proposed LSS framework aligns with project management best practices, enabling organizations to streamline execution, reduce variability, and drive continuous improvement across diverse project environments. It incorporates Core LSS Principles to foster efficiency and a culture of continuous improvement, the DMAIC Framework for structured problem-solving and sustainable enhancements, and Key Performance Indicators (KPIs) to measure efficiency, quality, and project success. By bridging traditional project management methodologies with advanced analytical capabilities, this framework offers a structured yet adaptable approach that enhances decision-making, operational efficiency, and value creation. Its seamless integration with Agile, hybrid project management models, and digital transformation initiatives ensures responsiveness to evolving business challenges and technological advancements. Ultimately, this LSS-driven approach redefines project management excellence, equipping organizations with the methodologies and insights needed to achieve long-term success, maintain a competitive edge, and drive sustainable growth in an increasingly complex and dynamic environment.