It has been shown that the most hazardous heavy metals that are constantly emitted into the environment are arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg). These metals can be found in both naturally occurring and artificially produced fertilizers, industrial processes, and waste disposal. Due to ongoing exposure to heavy metals, bioaccumulation of As, Pb, Cd, and Hg takes place in a variety of organs in chickens, primarily the kidneys, liver, reproductive organs, and lungs. Chemical, biological, or physical risks can be connected to animal feed. Poultry feed contamination can come from negligent or intentional handling, storage, and transportation practices. Because of the increased concentration of these heavy metals in these tissues—primarily the brain, liver, kidneys, and reproductive organs—chronic exposure to low doses of As, Pb, Cd, and Hg can alter the microscopic structure of these tissues. This puts human health at risk when consuming chicken or poultry. Risks to food safety should be carefully considered in order to reduce unfavorable side effects in both people and animals. Governments should therefore implement stringent measures to prevent any harmful contamination that could endanger public health. This review presents a discussion of bioaccumulation of As, Cd, Pb, and Hg in poultry with the associated problem of consumption of poultry and human health.