Research Article
Sero-Detection of Coxiella Burnett (Q fever) Infection Anti-Antibodies Igg and Igm among Spontaneous, Recurrent Miscarriage Women in Gezira State, Sudan -Case-Control Studies 2018
Shimaa Sharaf Eldin Mohamed Abbas, Mogahid Yaguob Abdegadir Ahmed, Abdamalik Hassab elrsoul Abdamalik, Ahmed Jdeed Essa Suliman, Ali Ahmed Ali Yousef, Ali Omer Mohammed Abdudafea, A. A. Osman, Mosab N
Middle East Research Journal of Medical Sciences; 70-75.
DOI: 10.36348/merjms.2024.v04i04.001
Background: Q fever is a zoonosis caused by the bacterium Coxiella burnetii and is associated with epizootic abortion in ungulates. In humans, the role of Q fever during pregnancy has been recently questioned. Objectives: Thus, the goal of this study was to investigate the seroprevalence of C. Burnett infection among pregnant women in Gezira state, Sudan as well as the relationship between spontaneous recurrent abortion and pregnancy. Methods: This study included 90 women, half of whom had recurrent spontaneous abortion (RSA) and the other half had successful pregnancies. Blood samples were taken simply randomly, with ethical considerations, and using open ended closed questionnaire, prepared samples, and kept at -20°C. The seroprevalence of IgG and IgM antibodies against C. burnetti was determined using a commercial enzyme-linked immunosorbent assay test kit. Means of frequencies plus standard error, Chi2, and in depending sample t-test and logistic regression univariate and multivariate tests have been used. Result: The overall prevalence of C. burnetii in the study population sera was (37/90) 41.11 percent, with 5(11.1%) and 11(24.4 %) positive miscarriages in pregnant women for C. Burnetti IgM and IgG, respectively. While in nonmiscarriage were 8 (17.8 %) and 13 (28.9 %) positive for IgM (OR .578, CI-95% .174-1.926, P .372), and IgG (OR .796, CI-95% .312-2.032, P .634), respectively. Other significant risk factors detected in the study were age(OR 5, CI-95% 2-13, P 0.001), biomax index (OR 5, CI-95% 2-12, P 0.001), Diabetic patients (OR 11,1CI-95% 11 -11.38 P 0.000), disorder of thyroid (OR 8,9 CI-95% 8.1 -9 P 0.000), microcytic hypochromic anemia (OR 11, CI-95% 1.1 -110.2 P 0.04), Menstruation Cycle (OR 3.8, CI-95% 1.2 -11.5, P 0.02), vaginal bleeding(OR 6.4 CI-95% 2.1-19.2, P 0.001), pre-eclampsia(OR 16.1, CI-95% 1.9-131.1, P 0.01), and miscarriage family history(OR 2.9, CI-95% 2.8 -9.8, P 0.000), RDWC(OR 4.4, CI-95% 1.8 -10.9, P 0.002), RDWSD (OR 19.2 CI-95% 5.2 -71.1, P 0.000). Conclusion: The study concluded that the seroprevalence of Coxiella burnetii among miscarriage and nonpregnant women in Gezira State was dissociation with miscarriage. While selection risk factors associated with miscarriage include age, biomaxindex, Diabetic patients, a disorder of the thyroid, menstruation Cycle, vaginal bleeding, pre-eclampsia, miscarriage family history, microcytic hypochromic anemia, RDWC, and RDWSD.
Research Article
The Correlation of HbA1c with Serum Electrolytes among Type 2 Diabetic Patients in Atbara, River Nile State, Sudan
Khalda Sid Ahmed M. Seed, Sufian Khalid M. Noor, Ghanem Mohammed Mahjaf, Mosab Nouraldein Mohammed Hamad
Middle East Research Journal of Medical Sciences; 76-81.
DOI: 10.36348/merjms.2024.v04i04.002
Background: Diabetes mellitus in Sudan is a growing health problem that is associated with poor glycemic control in all socio-economic classes. This is a study that was conducted in Naserldeen Karamalla diabetic center located at Atabara River Nile state. Aims: The study aimed to evaluate the relationship between glycated hemoglobin (HbA1c) and serum electrolytes in type 2 diabetic patients. Methods: The present study was a Cross-sectional, descriptive hospital-based study. A total of 500 type 2 diabetics with ages ranging from 15 to 87 years volunteered to participate in this study. The glycated hemoglobin (HbA1c), and serum electrolyte & were measured with standard procedure. The statistical analysis was done by using SPSS version 20. Results: The mean HbA1c was 10.8±6.6 %. (96.6%) of the patients who had poor glycemic control (HbA1c >60.5) the mean Mg, Ca, Na, K, and Cl was 2.06±0.68, 9.1 ±3.7, 140.9 ±7.0, 3.9 ±0.41 and101.04 ±7.7 respectively. In this study, the correlation between Mg+2 and HbA1c was statistically insignificant (P. value =0.765) and between Ca 2+ and HbA1c was statistically insignificant (P. value = 0.586). Insignificant correlation between Na+ and HbA1c P value = 0.283). An inverse relation between HbA1C and K+ (P. value = 0.020). Conclusion: HbA1c and serum potassium were negatively correlated while sodium, calcium, magnesium, and chloride had an insignificant correlation.
Research Article
Role of Prolotherapy in Thermal Burns
Dhinesh S, Dr. Ravi Kumar Chittoria, Bharat Prakash Reddy J
Middle East Research Journal of Medical Sciences; 82-85.
DOI: 10.36348/merjms.2024.v04i04.003
Burn wounds are the major problem all over the world. Many therapies have been introduced for the management of burn wounds. Management of these wounds is often challenging. But there is no well-established method that accelerates the wound healing rate. Prolotherapy is a method that involves injecting some irritant locally in the wound that is claimed to fasten the healing. This article discusses about the role of prolotherapy in wound bed preparation.
Review Article
Evaluation of the Efficiency of Neural Enolase (NSA) in the Diagnosis of Viral Encephalitis: A Medical Review
Carlos Henrique Marchiori, Marco Vinícios de Oliveira Santana, Klebert de Paula Malheiros
Middle East Research Journal of Medical Sciences; 86-99.
DOI: https://doi.org/10.36348/merjms.2024.v04i04.004
Encephalitis is an inflammation that occurs in the brain when a virus in some cases, bacteria attack it directly, and can also be triggered by other factors. It is an inflammatory process of the meninges, the membranes that cover the central nervous system. Enolase isoenzyme found in neuronal and neuroendocrine tissues. Its levels in tissues other than erythrocytes are negligible. Its measurement is useful for monitoring tumors of neuroendocrine origin, such as neuroblastoma, pheochromocytoma, medullary thyroid carcinoma, small cell lung carcinoma, melanoma, and some pancreatic tumors. NSE concentrations in cerebrospinal fluid (CSF) are often elevated in diseases that result in relatively rapid neuronal destruction. This review aims to evaluate the efficiency of neural enolase (NSA) in diagnosing viral encephalitis. The methodology used an integrative literature review and a synthesis process to develop the study, expand the understanding of knowledge, and achieve the expected results. The integrative literature review is a method that aims to synthesize results obtained in research on a topic or issue, in a systematic, ordered, and comprehensive way. It is called integrative because it provides broader information on a subject/problem, thus constituting a body of knowledge. To carry out the study, a search for scientific articles was carried out through the Virtual Health Library, in the SCIELO, LILACS, and PUBMED databases, using the terminologies registered in the Health Sciences descriptors, encephalitis, enolase, virus, and diagnosis.
Research Article
CHIA SEEDS: Novel Considerations in Therapeutics
Shah Murad, Iftekhar Yousaf, Saleemullah Lashari, Nikhar Zainab, Seema Saifuddin, Imtenan Sharif, Sibghatullah Sangi, Abrar Hussain Azad
Middle East Research Journal of Medical Sciences; 100-104.
DOI: https://doi.org/10.36348/merjms.2024.v04i04.005
In this study we evaluated and compared hypolipidemic efficacy of chia seeds and niacin. The study was conducted at National hospital, Lahore Pakistan from August 2019 to December 2019. Ninty hyperlipidemic patients were selected from cardiology and medical wards of the hospital. They were divided in three groups, one on placebo, another on chia seeds and third one on Niacin. After one and half month, significant changes (p value ranging from <0.05 to <0.001) were observed in their FBS, LDL and HDL-cholesterol. Conclusion of the study was to recommend use of chia seeds and Niacin for prevention and treatment of diabetes mellitus type 2 and secondary hyperlipidemia with good patient compliance.
Research Article
Characteristics of Venomous Coleopterans and Their Venom with Therapeutic Power (Insecta: Coleoptera)
Carlos Henrique Marchiori, Marco Vinícios de Oliveira Santana, Klebert de Paula Malheiros
Middle East Research Journal of Medical Sciences; 105-115.
DOI: https://doi.org/10.36348/merjms.2024.v04i04.006
The medical importance linked to these beetles is because they have a terpene in their hemolymph insect blood that is soluble in various organic solvents, but practically insoluble in water, cantharidin. Only synthesized male cantharidin is stored until mating and transferred to the female at the time of copulation. When molested, these insects expel the toxin through the membranous joints of the body, causing vesicles similar to burns on human skin. Meloid beetles generate a poisonous chemical compound to, among other things, defend themselves from their predators. An international research team involving the Complutense University of Madrid has shown that cantharidin is toxic to several common parasites. The results explain that some birds, such as the great bustard, ingest this type of beetle, among other beneficial properties, due to the antiparasitic activity of cantharidin. The objective of this manuscript was to describe the characteristics of venomous coleopterans and their venom with therapeutic power (Insecta: Coleoptera). This is a narrative review of the literature, which is indicated to explain and discuss a certain subject from a theoretical or contextual perspective, in a to allow the reader to acquire and/or update knowledge on a specific topic. The search for scientific articles that made up this review was carried out on Google Scholar, Biological Abstract, HAL, Qeios, ResearchGate, Scielo, and SSRN. The following descriptors in Health Sciences (DeCS) were used: biological therapy, larva, wound, debridement, and healing. The following inclusion criteria were considered: Original articles and reviews, published nationally and internationally in full, available electronically, and published in Portuguese, English, and Spanish. The exclusion criteria were dissertations, theses, monographs, and conclusion work, duplicates, and those that required payment to access the content in full.
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