Research Article
Study Neuromodulation in People Who Practice Physical Activity, Assist in the Evaluation of Athletes, the Benefits of Jiu Jitsu Neuroplasticity for the Autistic Brain, and Muscle Memory
Marco Vinícios de Oliveira Santana, Carlos Henrique Marchiori, Klebert de Paula Malheiros, Fernando Marques Faustino
Middle East Research Journal of Medical Sciences; 239-258.
https://doi.org/10.36348/merjms.2025.v05i03.002
Abstract: Neuromodulation can enhance neuroplasticity, which improves. For example, it can be used to treat disorders such as depression, schizophrenia, and Parkinson's disease, or to restore motor, cognitive, or speech functions. Physical activity offers multiple health benefits for everyone, at any age, and for both women and men. Neuromodulation for those suffering from muscle overload, including: Pain reduction, improved neuromotor control, increased muscle performance, and accelerated rehabilitation, children with autism, developing social skills, improving motor coordination, and increasing confidence. Practicing Jiu-Jitsu promotes neuroplasticity, the brain’s ability to adapt and form new neural connections. This can be especially beneficial for children with autism, as Jiu-Jitsu helps strengthen areas of the brain that may be less developed. Neuromuscular memory refers to the body's ability to recover strength and muscle mass more quickly after a period of inactivity, due to adaptations in the nervous system and muscles. The objective of the manuscript is to understand how neuromodulation occurs for people who perform physical activity, to help in the evaluation of athletes, the neuroplasticity benefits of Jiu Jitsu for the autistic brain and muscle memory. This work is a literature review, based on scientific articles. The inclusion criteria for the articles that were part of this review were: articles published in the last 15 years and published in Portuguese and English on the subject, carefully selected from databases such as Scielo, PubMed, Google Scholar, Capes Portal, Latin American and Caribbean Literature in Health Sciences, Scielo, SSRN and ResearchGate using the following criteria keyword: neuromodulation, neuroplasticity, neuromuscular memory, port, physical activity.
Review Article
Study of the Relationship between Cannabidiol and Motor Neuron Disease
Ronaldo Freua Bufaíçal Filho, Klebert de Paula Malheiros, Carlos Henrique Marchiori
Middle East Research Journal of Medical Sciences; 259-268.
https://doi.org/10.36348/merjms.2025.v05i03.003
The main functions of motor neurons include regulating muscle contraction, controlling posture and balance, coordinating movements, and transmitting sensory information to the central nervous system. They are essential for carrying out daily motor activities and maintaining homeostasis in the body. Their unique structure and vital functions make them fundamental parts of the functioning of the nervous system and the regulation of the body's motor activities. Motor Neuron Disease(MND), the target mechanism of cannabinoids, to provide an antispastic effect, occurs through receptors in the synapses of the Central Nervous System(CNS). This mechanism allows the inhibition of the pre-synapses and reduces the release of glutamatergic neurotransmitters. Thus, it was shown that cannabidiol was well tolerated and presented the first evidence of providing control of spasticity. The manuscript aims to study the relationship between cannabinoids and motor neuron disease. A literature review is a study based on collecting selected materials and bibliographies, through a precise search in the scientific community's available databases.
Research Article
Investigate Quercetin in Chelation Therapy and Other Important Therapies
Marco Vinícios de Oliveira Santana, Klebert de Paula , Carlos Henrique Marchiori, Èrico Meirelles de Melo
Middle East Research Journal of Medical Sciences; 269-284.
https://doi.org/10.36348/merjms.2025.v05i03.004
Abstract: Chelation therapy is a biologically based practice that develops a chemical reaction in which certain molecules bind to metal atoms, such as calcium, copper, ferrous, or prickly pear. Chelating medications are linked to metastasis so that they can be excreted from the body. Quercetin is a substance from the group of flavonoids, with powerful antioxidant activity. When used correctly and associated with a healthy lifestyle, it has anti-inflammatory properties, protection against cancer, cardiac protection, and anti-aging. This manuscript aims to investigate quercetin in chelation therapy and other important therapies. This is a bibliographic review of the literature on the importance of keratin in chelation therapy and other functions. The data collection searches in two databases of articles that provide information in English: STM (Science Translational Medicine) and a database that brings together works published in Latin America, and the Scientific Electronic Library Online. In addition to the cited bases, Google Scholar was used in the English and Portuguese versions.
Research Article
Quantitative Assessment of Barriers to Sexual and Reproductive Health Services Among Women and Girls Living with HIV in Nigeria: A Cross-sectional Study
Irima Odo
Middle East Research Journal of Medical Sciences; 285-292.
https://doi.org/10.36348/merjms.2025.v05i03.005
Abstract: Despite global and national commitments to sexual and reproductive health and rights (SRHR), women and girls living with HIV (WGLHIV) in Nigeria face numerous barriers to access SRHR services. These barriers are multi-faceted, rooted in stigma, legal constraints, socio-economic challenges and health system inadequacies. This study quantifies the SRHR barriers faced by WGLHIV in Nigeria using thematic data from a previous qualitative evidence synthesis. Data were extracted from published qualitative studies that reported quantifiable insights into SRHR challenges faced by WGLHIV. Frequency distributions, cross-tabulations and odds ratios were used to analyse the prevalence and impact of six core barrier categories: healthcare worker discrimination, stigma and social exclusion, legal/policy restrictions, economic constraints, lack of autonomy and poor health infrastructure. Healthcare worker discrimination (32%) and stigma (28%) were the most common barriers and strongest predictors of SRHR service denial with odds ratios of 2.5 and 2.3 respectively. Age-stratified analysis showed that young women (15-24 years) experience higher levels of stigma, discrimination and economic challenges. SRHR access for WGLHIV in Nigeria is compromised by intersecting structural and social barriers. Addressing these requires policy reforms, healthcare delivery reforms, community engagement and legal protections. Data-driven and age-responsive interventions are key to achieving health equity and human rights for this marginalised group.
Research Article
Lactose Intolerance in Patients with Diarrhea-Predominant Irritable Bowel Syndrome in a Tertiary Care Hospital in Bangladesh
Chanchal Kumar Ghosh, Aditi Sarker, Abdur Rahim Miah, Projesh Kumar Roy
Middle East Research Journal of Medical Sciences; 293-300.
https://doi.org/10.36348/merjms.2025.v05i03.006
Background: Diarrhea-predominant irritable bowel syndrome (IBS-D) and lactose intolerance frequently coexist, presenting overlapping gastrointestinal symptoms that complicate diagnosis and management. This study aimed to determine the prevalence of lactose intolerance among IBS-D patients in Bangladesh and to identify associated clinical features and risk factors. Methods: A cross-sectional observational study was conducted among 392 IBS-D patients at Bangabandhu Sheikh Mujib Medical University (BSMMU). Lactose intolerance was diagnosed using the Lactose Tolerance Test (LTT). Clinical symptoms, dietary patterns, comorbidities, and risk factors were assessed using structured interviews and validated scoring systems. Statistical analysis included Chi-square tests and logistic regression. Results: Lactose intolerance was identified in 57.7% of IBS-D patients using LTT. Lactose-intolerant patients experienced significantly higher rates of abdominal pain (95.1% vs. 89.8%, p = 0.045), bloating (85.0% vs. 71.1%, p = 0.001), flatulence (77.9% vs. 60.8%, p < 0.001), and diarrhea occurring three or more times a day (67.7% vs. 49.4%, p < 0.001) compared to lactose-tolerant patients. Severe IBS symptoms were more common in the lactose-intolerant group (43.4% vs. 15.7%, p < 0.001). Significant associations were observed with family history of gastrointestinal illness (p = 0.015) and inverse association with lactose-rich diet (p < 0.001). Trends were noted for higher prevalence of PPI use, diabetes mellitus, and thyroid disorders among lactose-intolerant individuals. Conclusion: Lactose intolerance is highly prevalent among IBS-D patients in Bangladesh and is associated with more severe symptom profiles. Routine screening for lactose intolerance and individualized dietary interventions is recommended to improve clinical outcomes in this population.
Research Article
Comparison of Two Techniques in the Treatment of Magnetic Resonance Specific Phobia
Ahmet TELLI
Middle East Research Journal of Medical Sciences; 301-306.
https://doi.org/10.36348/merjms.2025.v05i03.007
Objective: Specific phobia is characterized by an irrational fear and avoidance behavior in response to particular stimuli. Magnetic Resonance (MR) phobia is considered one of the subtypes of specific phobia, manifested by intense anxiety and fear during MR scans, often triggered by claustrophobia or the loud sounds emitted by the machine. Hypno-Meditative Reprocessing Therapy and Hypnotic Jacobson Relaxation Techniques are two hypnotherapeutic methods with significant potential for treating MR phobia. The purpose of this study is to compare the effectiveness of Hypno-Meditative Reprocessing Therapy and Hypnotic Jacobson Relaxation Techniques in alleviating the fears of patients with MR phobia. Material and Method: The study population consists of patients aged 18-65 residing in Istanbul, diagnosed with MR phobia at educational and research hospitals affiliated with the Ministry of Health. Participants were randomly divided into two groups: the Hypno-Meditative Reprocessing Therapy Group and the Jacobson Relaxation Technique Group. Results: The Subjective Units of Disturbance Scale was employed to measure subjective anxiety levels related to the phobia. Significant differences were observed in the average scores between pre-test and post-test evaluations in both experimental groups. The efficacy of both treatment methods in reducing MR phobia was demonstrated. Conclusion: Our study revealed that Hypno-Meditative Reprocessing Therapy was more effective in reducing Subjective Units of Disturbance scores compared to the Jacobson Relaxation Technique.
Research Article
Study of Current Practices on Hospital Waste Management and Some of its Effects on Human Health in Kenya
Susan Muthoni Maina
Middle East Research Journal of Medical Sciences; 307-317.
https://doi.org/10.36348/merjms.2025.v05i03.008
Control of hospital environment is key to success of healthcare quality. Increasing emergence and spread of pathogenic bacteria is of great concern and continues to challenge infection prevention and epidemiology practice. This study aimed at providing information about the management of hospital environment and wastes in selected hospitals in Kenya namely Kenyatta National hospital and Referral (KNH, Public) and Kikuyu Mission Hospital (KMH- Private), the period of March 2020 to June 2020. Both are within similar locality. Simple random sampling was used to distribute a semi structured questionnaire among 246 health workers in each of the hospitals to capture data on management of hospital waste. Results from the study revealed that healthcare facilities whether public or private practiced inappropriate medical wastes management skills. The current practices are inappropriate due to lack of proper facilities and information of the individuals concerned.
Research Article
Study Current and Future Therapies in the Treatment of Cancer
Marco Vinícios de Oliveira Santana, Klebert de Paula Malheiros, Carlos Henrique Marchiori, Èrico Meirelles de Melo
Middle East Research Journal of Medical Sciences; 318-341.
https://doi.org/10.36348/merjms.2025.v05i03.009
Cancer is the second leading cause of death in the world. The most common types of cancer among men are: Pulmonary, prostate, colorectal, stomach, and hepatic, and the most common among women are breast, colorectal, pulmonary, cervical, and thyroid. The objective of this manuscript was to study current and future therapies in the treatment of cancer. Data were collected using a quantitative and descriptive approach, through books and the following databases: Scopus, SciVerse, Scientific Electronic Library Online, and the Academic Search Tool. The search was developed using the subject cancer, therapies, and treatment referred to in journals, through a review of the literature on the subject. In the initial search, the titles and abstracts of the articles were considered for the broad selection of likely works of interest, with the abstracts being highlighted.
Research Article
The Role of Music, Dance, Movement, and Frequency in the Process of Neuroplasticity
Marco Vinícios de Oliveira Santana, Klebert de Paula Malheiros, Carlos Henrique Marchiori, Èrico Meirelles de Melo
Middle East Research Journal of Medical Sciences; 342-359.
https://doi.org/10.36348/merjms.2025.v05i03.010
Recent studies have found that if movement is combined with music, dance, and frequency, the effects of these activities are greater than those provided separately. Both increase neuroplasticity by creating new pathways of neuronal connections through different mechanisms, and their synergistic action offers better results, as music and dance influence cognitive abilities. Music is a powerful stimulus for neuroplasticity. To verify the role of music, dance, movement, and frequency in neuroplasticity. This paper is a narrative review of the literature, which is intended to explain and discuss a given subject from a theoretical or contextual perspective, to allow the reader to acquire or update knowledge on a specific topic. The search for scientific articles in Google Scholar, Biological Abstracts, HAL, Qeios, ResearchGate, Scielo, and SSRN. The inclusion criteria considered were: original articles and reviews, published nationally and internationally in full, available electronically, and published in Portuguese, English, and Spanish.
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