Research Article
Effect of Combination of Some Phytoconstituents of Pharmacological Interest on Cutaneous Wound Healing in Diabetic Rats
Pradeep Deshmukh, Dhirendra Sanghais, Vaishali Kate, Atul Deshmukh, Sanjeevani Desai, Santosh Payghan
Middle East Research Journal of Medical Sciences; 42-51.
DOI: 10.36348/merjms.2023.v03i03.001
Persistent non-healing wounds present a substantial challenge in the context of diabetes management. This research delves into exploring the wound healing capabilities of a combination of natural plant-derived compounds, namely embelin, berberine, ferulic acid, and asiatic acid, in streptozotocin induced diabetic rats. Various wound models, including dead space, incision, and excision models, were employed to evaluate their impact. The phytoconstituents were carefully blended into an ointment formulation, with a concentration of 5% (w/w), specifically designed to cater to their individual strengths. Notably, diabetic rats exhibited a significant enhancement in wound closure and improved skin epithelialization. Furthermore, this combination of phytoconstituents exhibited efficacy when administered orally in both the incision and dead space wound models. In the incision wound model, granulation tissues were examined on the 8th day following the initial injury, and assessments were made for hydroxyproline, hexosamine, total protein. In streptozotocin-induced diabetic rats, both topical and oral applications of this combination revealed a marked increase in hydroxyproline, hexosamine, indicating a favorable impact on wound healing. Additionally, the combination led to a substantial improvement in wound breaking strength. When assessed in the dead space model, the combination notably increased the weight and breaking strength of granuloma tissue. These findings collectively point to the wound healing acceleration attributed to Combination in diabetic rats.
Research Article
COVID 19 Vaccinations and Its Impact
Shaista Ganai, Mohd Sarwar Mir
Middle East Research Journal of Medical Sciences; 52-54.
DOI: 10.36348/merjms.2023.v03i03.002
Vaccination with a 95% efficacy against disease could substantially mitigate future attack rates, hospitalizations, and deaths, even if only adults are vaccinated. Non-pharmaceutical interventions remain an important part of outbreak response as vaccines are distributed over time. To bring the lives to near normal, only option to attain it is mass vaccination in order to attain a herd immunity of >70 percent. A multicentric study was carried out two sites. A total of 160 patients were studied, 80 in a hospital set up and 80 in community. It was observed that severity of symptoms in cases who had received vaccination was less as compared to unvaccinated lot. Also the vaccination was viewed positively by the majority of the respondents.
Research Article
Unit Cost of Magnetic Resonance Imaging Scan at a Tertiary Care Teaching Hospital in India
Shaista Ganai, Mohd Sarwar Mir
Middle East Research Journal of Medical Sciences; 55-57.
DOI: 10.36348/merjms.2023.v03i03.003
Cost control programmes are not aimed at cutting the quality or quantity of services provided to the patient. They are aimed at increasing the performance efficiency of the healthcare team. Knowledge of unit cost is needed to assist planning for recurrent budget as an indicator of efficiency and to enforce pricing of services. The study revealed that the unit cost for MRI scan is Rupees 7432.7.
Review Article
Veterinary Pathology, Production Animals Medicine, and Food Inspection: One Health in Practice in Slaughterhouse
Pires I, Saraiva C, Silva F
Middle East Research Journal of Medical Sciences; 58-60.
DOI: 10.36348/merjms.2023.v03i03.004
Veterinary Pathology is crucial in understanding the diseases affecting animals, their causes, development, and changes in tissues and organs. Veterinarians who work with production animals are responsible for maintaining their health and productivity. Pathology is used to comprehend the nature of diseases, which leads to the implementation of treatment protocols and preventive measures. Slaughterhouse food inspection is crucial for ensuring that meat is safe for consumption. This process involves ante-mortem and post-mortem inspections to detect any signs of disease or abnormalities that could render the meat unsafe. This integrated approach within slaughterhouses practically demonstrates the One Health concept. The importance of considering animal health, human health, and environmental impacts together is underscored. Veterinary practices directly impact the safety and quality of food products, which has implications for public health.
Review Article
Insulin Induced Edema in a Patient with Type 3c (Pancreatogenic) Diabetes
Dr. Jacob Neil (MD), Dr. Asha Anne Jacob (MS)
Middle East Research Journal of Medical Sciences; 61-65.
DOI: 10.36348/merjms.2023.v03i03.005
Insulin edema is a rare complication of insulin therapy that can occur after the initiation and intensification of insulin commonly seen in Type 1 Diabetes with chronic hyperglycemia. Here, we report the occurrence of generalized edema in a 24-year-old man with Type 3 c (Pancreatogenic) diabetes due to chronic pancreatitis, early after the initiation and self- intensification of insulin. Various differentials were excluded, and resolution of edema was achieved after 3 weeks with diuretics. The incidence of Insulin edema being a rare occurrence and as a diagnosis of exclusion we present this case to increase awareness as it carries a good prognosis. We reviewed the current literature and the possible mechanisms behind this phenomenon.
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