Research Article
Effects of Herbs on Blood Pressure, Diabetes Mellitus, and Hyperlipidemia
Shah Murad, Zafar H Tanveer, Abdul Qudoos, Ajaz Fatima, Asia Firdous, M. Iqbal, Mohsin Ali Hassni, Soha Samreen, Usama Abdul Musawwir
Middle East Research Journal of Pharmaceutical Sciences; 1-5.
DOI: 10.36348/merjps.2024.v04i01.001
Overweight and obesity in youth is a worldwide public health problem. Overweight and obesity in childhood and adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidemia, hypertension and type 2 diabetes (T2D). Obesity and the type of body fat distribution are still the core aspects of insulin resistance and seem to be the physiopathologic links common to metabolic syndrome, cardiovascular disease and T2D. In presence of high levels of blood LDL particles, free radicals (ROS), macrophages, cytokines, platelets, histamine, 5HT get involved in LDL oxidation, leading to formation of atherosclerotic plaques which get deposited in endothelium of coronary arteries causing coronary artery disease (CAD). Psyllium fibers and Ficus Carica (FC) are being considered to be useful in treating hyperlipidemia, hypertension, and hyperglycemia. This study was conducted to determine hypotensive, hypolipidemic, and hypoglycemic potential of Psyllium husk and FC. Study was conducted in National hospital, Lahore, Pakistan from January to April 2019. Seventy five hyperlipidemic, hypertensive and diabetic patients were enrolled selected from the hospital with their consent. They were divided in three groups ie 25 patients in each group. Group-1 was on placebo, group-2 was on 15 grams psyllium husk to be used in three divided doses. Group-3 was on 12 grams FC to be taken in three divided doses daily for two months. Their Lipid profile, FBS, and hypertension were determined before and after two months therapy by these two agents. Two analyze data we used SPSS version 10.01.001 2015 and t test was applied to determine changes in the tested parameters. In two months therapy by psyllium husk in 24 patients TG, TC, LDL-c was reduced 21.48, 10.09, 24.17 mg/dl respectively. HDL was increased 12.38 mg/dl in this group. FBS reduction was 28.66 mg/dl, systolic BP 6.30, and diastolic BP reduced in this group 7.52 mm of mg. We then concluded that FC and PH have good enough potential to normalize lipid profile, reduce BP, and FBS in patients suffering from metabolic syndrome.
Research Article
Decreasing Waiting Time for Outpatient Chronic Prescriptions Pickup Using Drive through 24/7 Automated Dispensing Carousel System at King Salman Military Hospital (KSAFH)
Major Olayan Alatawi
Middle East Research Journal of Pharmaceutical Sciences; 6-13.
DOI: 10.36348/merjps.2024.v04i01.002
Extended waiting periods have an effect on healthcare accessibility and delivery. The main purpose of drive through 24/7 automated dispensing carousel system is reducing the necessity for patient to visit the hospital to dispense his/her chronic medications, increasing patient's convenience and relieving congested parking spaces in the hospital. Several methods have been implemented in other countries to reduce patient waiting time. Some of which include automated dispensing system, staff scheduling plan, postal-delivery prescription, and redesign of pharmacy workflow [1-4]. In SAUDI ARABIA, one of the methods adopted was implementation of drive through 24/7 automated dispensing carousel system (DAD). DAD was developed to make patients' chronic prescription pickups easier. The hospital has implemented Capsa Healthcare’s RoboWall as a drive-through model for the first time in the global market at King Salman Armed Forces Hospital (KSAFH) to facilitate the convenient delivery of prescription drugs to patients. DAD is a collection of innovative dispensing systems that offers patients new concepts for dispensing their prescription. Pharmacy tech workstations generally have barcode-driven internal workstations, flat screen displays facing patients, Robowall software, and SMS (text messaging) modules. This project will assess were to (1) assess the effectiveness of drive through 24/7 automated dispensing carousel system in improving waiting time for outpatient chronic prescriptions pickup and determine the feasibility of this system in a busy tertiary military hospital. Data will be extracted from routinely queuing system, hospital information systems, and patient experience. The aim of this study will focus on and explore the current practice and its barriers to waiting time for outpatient chronic prescriptions pickup. Where possible, generalize the study to other military hospitals among the Ministry of Defense and other health care providers at Saudi Arabia.
Research Article
A Description and Relevant Information Profile of the Medicinal Plant Helicteres Isora Linn
Md Nahid Hasan, Md Aktaruzzaman, Md Ferdous Hossain, Sheikh Tarikul Islam Tusher
Middle East Research Journal of Pharmaceutical Sciences; 14-21.
DOI: 10.36348/merjps.2024.v04i01.003
The medicinal plant Atmora (Helicteres isora Linn.) is used to treat a variety of illnesses. The fruit of this plant is commonly referred to as Marodphali, Enthani, because of its screw-like appearance. Atmora is a traditional medicine used to treat new-born constipation, diarrhea, and snake bites. H. isora grows to a height of five to eight meters as a small tree or large shrub. Its ovate, hairy leaves with serrated margins are arranged alternately, and its bark is grey. Its fruits are green when raw, brown or grey when dried, and twisted, with a screw at the tip. Its flowers are brick red or orange-red. Antioxidants, carbohydrates, proteins, fiber, calcium, phosphorus, and iron are all rich in H. isora. This study aims to describe about botanical characteristics, uses, ethno-medicinal properties and therapeutic importance of it.
Research Article
Fenugreek Leaves and Lemon are Mild to Moderately Effective Hypolipidemic Herbs to Lower Total Plasma Cholesterol, Triglycerides, and LDL Cholesterol in Primary and Secondary Hyperlipidemic Patients
Shah Murad, Mohsin Ali Hassni, Zafar H Tanveer, Farzana Majeed, Ajaz Fatima, Asia Firdous, Soha Samreen, Usama Abdul Musawwir
Middle East Research Journal of Pharmaceutical Sciences; 22-26.
DOI: 10.36348/merjps.2024.v04i01.004
In recent decades, some researchers assert that other newer lipid measurements, including non-HDL-C, apolipoprotein (apo) A-I, apoB, and lipid ratios, are superior to traditional LDL-C in predicting adverse outcomes in general population. Some researchers even suggest that apoB can replace the standard “lipid profile” as a target for motoring and therapy in at-risk patients. High plasma lipids interact with free radicals in human body leading to develop coronary artery disease. We in this study have compared hypolipidemic effects of Fenugreek, Curcuma longa, and Lemon. Study was conducted at Jinnah Hospital Lahore-Pakistan from January 2022 to May 2022. Ninety hyperlipidemic patients of age group 19 to 70 were included in the study. Exclusion criteria were diabetic, alcoholic additives, hypertensive patients and those whose kidney or liver functions were impaired. Consent was taken from all participants. Their base line lipid profile was taken in biochemistry laboratory of the hospital. They were divided in three groups i.e. 30 patients in each group. Group-I was advised to take 500 mg of Curcuma longa (haldi) mixed in fresh milk without cream, thrice daily for two months. Group-II patients were advised to take 100 grams of Fenugreek leaves mixed with salad in each meal (thrice daily) for the period of two months. Group-III patients were advised to take 40 ml of fresh lemon juice mixed with 40 ml mineral water thrice daily for two months. They all were advised not to take heavy meal rich with any type of fat like junk food etc. One hour daily brisk walk was advised to all participants. 15 days follow up visit was scheduled for them. After two months their lipid profile was re-determined. When results were compiled and statistically analyzed by applying paired ‘t’ test, it revealed that Curcuma longa decreased total cholesterol, TG, LDL cholesterol 16.10, 20.01, and 17.59 mg/dl respectively. Fenugreek decreased total cholesterol, TGs, and LDL cholesterol 14.70, 17.33, and 17.06 mg/dl respectively. Lemon in two months therapy decreased total cholesterol, TGs, and LDL cholesterol 15.45, 10.13, and 11.97 mg/dl respectively. None of the above mentioned herbs raised HDL cholesterol significantly. It was concluded from this research work that Curcuma longa, Fenugreek leaves and Lemon are mild to moderately effective hypolipidemic herbs to lower total plasma cholesterol, triglycerides, and LDL cholesterol but have no potential to raise HDL cholesterol when analyzed biostatistically.
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